WebChickens were immunized with a synthetic peptide/keyhole limpet hemocyanin (KLH) conjugate. The peptide corresponded to a region of Myelin PLP, but are shared between the human (NP_000524, PLP1 isoform 1 and PLP1 isoform 2 … WebDefects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1) [MIM:312080]; also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked …
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WebIn elaborating and maintaining myelin sheaths on multiple axons/segments, oligodendrocytes distribute translation of some proteins, including myelin basic protein (MBP), to sites of myelin sheath assembly, or MSAS. ... In both studies, MBP mRNA was by far the most abundant mRNA in isolated myelin. MOBP and PLP1 mRNAs were more … WebFeb 9, 2005 · In contrast, myelin sheaths are formed in the spinal cord, although the extent of myelination is severely reduced. At the molecular level, we find that Olig1 regulates transcription of the major myelin-specific genes, Mbp , Plp1 , and Mag , and suppresses expression of a major astrocyte-specific gene, Gfap . download dry bar comedy app
YY1 negatively regulates mouse myelin proteolipid protein (Plp1) …
WebNov 3, 2011 · YY1 (Yin and Yang 1) is a multifunctional, ubiquitously expressed, zinc finger protein that can act as a transcriptional activator, repressor, or initiator element binding protein. Previous studies have shown that YY1 modulates the activity of reporter genes driven by the myelin PLP (proteolipid protein) (PLP1/Plp1) promoter. However, it is … WebOct 11, 2024 · PLP1 is located on the X-chromosome and encodes myelin proteolipid protein (PLP), the most abundant protein in central nervous system myelin. Generally, point mutations in PLP1 result in X-linked dysmyelinating disorders, such as Pelizaeus-Merzbacher disease (PMD) or spastic paraplegia type 2 (SPG2). However, several case … WebDefects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1) [MIM:312080]; also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. ... IHC-Fr image of myelin PLP staining on Mouse sciatic nerve sections using … clarkson lpn iv