Irinotecan topoisomerase 1 inhibitor
WebDec 1, 1997 · Irinotecan (CPT-11), a semi-synthetic derivative of camptothecin, is approved in the United States for the treatment of colorectal cancer. Ongoing clinical trials with CPT-11 show a 13% to 32% response rate when it is used singly or in combination with other chemotherapeutic agents such as 5-fluorouracil. WebIrinotecan (CPT-11, (+)-Irinotecan) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. Features Irinotecan is a prodrug that …
Irinotecan topoisomerase 1 inhibitor
Did you know?
Irinotecan is a topoisomerase inhibitor —it blocks the topoisomerase I enzyme, resulting in DNA damage and cell death. ... The molecular action of irinotecan occurs by trapping a subset of topoisomerase-1-DNA cleavage complexes, those with a guanine +1 in the DNA sequence. See more Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer. For colon cancer it is used either alone or with fluorouracil. For small cell lung cancer it is … See more Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen See more Camptothecin, one of the four major structural classifications of plant-derived anti-cancerous compounds, is a cytotoxic alkaloid which … See more Irinotecan is converted by an enzyme into its active metabolite SN-38, which is in turn inactivated by the enzyme UGT1A1 by glucuronidation. See more The most significant adverse effects of irinotecan include diarrhea, nausea and vomiting, neutropenia and fever, infections of blood or lungs (sepsis, pneumonia), shock, dehydration, kidney failure and thrombocytopenia (low levels of blood platelets). See more Administration Irinotecan can be administrated by 30- or 90-minute intravenous infusions of either 125 mg/m weekly for four of every six weeks or 350 mg/m … See more Irinotecan received accelerated approval from the U.S. Food and Drug Administration (FDA) in 1996, and full approval in 1998. Names See more WebIrinotecan (CPT-11, (+)-Irinotecan) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. CAS No. 97682-44-5 Selleck's Irinotecan (CPT-11) has been cited by publications Cell Death Dis,202414 (1):64 Cancers (Basel),202414 (5)1230 Oncotarget,202413:1094-1108 Cell Death Discov,20248 (1):296
WebDec 1, 1997 · Topoisomerase I inhibitors are a new class of anticancer agents with a mechanism of action aimed at interrupting DNA replication in cancer cells, the result of which is cell death. ... Irinotecan (CPT-11), a semi-synthetic derivative of camptothecin, is approved in the United States for the treatment of colorectal cancer. Ongoing clinical ... WebMay 27, 2015 · Irinotecan (brand name Camptosar) is a topoisomerase I inhibitor widely used in the treatment of cancer. It is most frequently used in combination with other …
WebTopoisomerase (TOP) inhibitors are chemotherapeutic drugs that cause DNA double-strand breaks during DNA replication. These can be repaired by homologous recombination, but some tumors, such as triple-negative breast cancer, have defects in … WebTopoisomerase inhibitors block the ligation step of the cell cycle, which generates DNA single- ...
WebDrug Description. Irinotecan. An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. Topotecan. An antineoplastic agent used to treat …
WebTopoisomerase inhibitors block the ligation step of the cell cycle, which generates DNA single- and double-strand breaks, leading to apoptotic cell death. Topoisomerase I … dharma house columbus ohioWebMar 21, 2024 · Irinotecan, a prodrug of 7-ethyl 10-hydroxycamptothecin (SN38), is an antineoplastic agent of the topoisomerase (Top1) inhibitor class that is widely used to treat colorectal and other gastrointestinal cancers. The pharmacokinetics and metabolism of irinotecan and SN38 in humans are well described in the literature [ 1, 2, 3, 4, 5 ]. dharma initiative clockWebThis medication is classified as a "topoisomerase 1 inhibitor." (For more detail, see "How this drug works" section below). What Topotecan Is Used For: This medicine is used to treat cancer of the ovaries when other treatments have failed. Topotecan may also be used in certain types of lung cancer (small cell lung cancer). ... ciffa companyWebNov 22, 2011 · The topoisomerase I (Top 1) poison irinotecan is an important component of the modern treatment of colorectal cancer. By stabilising Top 1-DNA complexes, … cifey-showWebIrinotecan ( (+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. For research use only. We do not sell … dharma headphonesWebTopoisomerase I inhibitors represent a widely used class of antineoplastic agents that promote both single-stranded and double-stranded breaks in the DNA of tumor cells, leading to tumor cell death. Topotecan and irinotecan are the clinically relevant derivatives of the parent drug, camptothecin. As is the case with many if not most anticancer ... dharma in hinduism definitionWebAug 17, 2024 · BAY 1895344 Plus Topoisomerase-1 (Top1) Inhibitors in Patients With Advanced Solid Tumors, Phase I Studies With Expansion Cohorts in Small Cell Lung … dharma initiative patch silver