WebThe transcription factor hypoxia-inducible factor (HIF)-1α drives this metabolic reorganization. Oxygen levels, as well as other factors, control the activity of HIF-1α. In addition, the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) modulates tumor-specific immunity and can also participate in metabolic remodeling. Web9 de ago. de 2024 · HIF-1 activation leads to increased oxygen and nutrient delivery via enhancing angiogenesis and erythropoiesis (41,42) and improving oxygen utilization in metabolism . Activated HIF-1 is either directly or indirectly associated with the upregulation of GLUTs and glycolytic enzymes in glycolysis and lactate production (45,46) .
STING regulates metabolic reprogramming in macrophages via HIF …
Web11 de abr. de 2024 · Third, although all HIF-PHIs are potent inhibitors of PHD1, PHD2, and PHD3 and stabilize HIF-α(66), they display differences in their pharmacokinetic and pharmacodynamic profiles. Therefore, the differences in the effects of different HIF-PHIs on iron metabolism and inflammation require further exploration. 5. Conclusions WebThe prolyl hydroxylase domain (PHD) / hypoxia-inducible factor (HIF) axis is a critically important oxygen-sensing pathway that mediates tissue adaptation to low oxygen environments primarily via the transcriptional regulation of gene expression. The laboratory of Volker H. Haase investigates the key components of this pathway and their ... ezy erp
HIF-1: upstream and downstream of cancer metabolism - PMC
Web1 de jun. de 2024 · HIF-1 and HIF-2, the most extensively studied HIF transcription factors, facilitate oxygen delivery and cellular adaptation to hypoxia by regulating a wide spectrum of hypoxia responses such as angiogenesis, anaerobic glucose metabolism, mitochondrial biogenesis, and others. 18 The list of genes that are directly HIF-regulated is large and … WebHIF-1 target genes involved in glucose and energy metabolism. HIF-1 activates the transcription of SLC2A1 and SLC2A3, which encode the glucose transporters GLUT1 … WebRepositorio. Portal de Datos Abiertos UNAM, Colecciones Universitarias. 2,045,979. Repositorio de la Dirección General de Bibliotecas y Servicios Digitales de Información. … ezy emerald