Cisplatin resistance mechanism
WebJan 10, 2014 · Here, we review the molecular mechanisms of cisplatin resistance. These include methods to reduce cisplatin bioavailability within a cell, and defects in the machinery that produces cell death following cisplatin-induced DNA damage. While overcoming these mechanisms is a potential therapeutic approach that can increase … WebUnfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation.
Cisplatin resistance mechanism
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WebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased … WebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways …
WebJul 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decerased intracellular concentration due to decreased … WebOct 5, 2014 · The proposed mechanisms of cisplatin resistance include changes in cellular uptake and efflux of cisplatin, increased biotransformation and detoxification in the liver, and increase in DNA repair and anti-apoptotic mechanisms (Gottesman, Fojo et al., 2002) . To overcome resistance, cisplatin is commonly used in combination with some …
WebDDP has gradually become the standard chemotherapy method for chronic lung adenocarcinoma and postoperative grade II and III lung adenocarcinoma. 8 Although lung adenocarcinoma reacts well in the initial stage of standard cisplatin chemotherapy, significant DDP resistance develops before chemotherapy (primary resistance) or … WebSep 9, 2014 · Another resistance mechanism to cisplatin and oxaliplatin is increased glutathione concentration, which inactivates platinum compounds before DNA damage occurs. Metallothioneins are small cysteine-rich proteins involved in metal detoxification and may play a role as stress proteins in response to platinum complexes. 76 Once inside …
WebApr 22, 2024 · Resistance to cisplatin, a platinum-based drug used as first-line chemotherapy treatment is a prominent example that has been extensively studied in …
WebOct 13, 2024 · An overview of the categories of platinum resistance mechanisms represented in the database is provided below. Regulation of drug entry, exit, accumulation, sequestration, and detoxification... hifi yeovilWebJun 15, 2024 · Based on the above reasons, this study mainly explored the molecular mechanism of DDP resistance in TNBC. We argue that the miR-133b-fibroblast growth factor receptor 1 (FGFR1) axis may mediate the tumor growth and DDP resistance of TNBC by regulating the Wnt-β-catenin pathway. miR-133b is related to the survival and … hifi youtubeWebFeb 25, 2024 · Autophagic flux in cisplatin-resistant ovarian cancer cells is caused by cisplatin. At present, the cytoprotective function of autophagy in cancer cells is considered a potential chemotherapy resistance mechanism. Most studies have suggested that targeting autophagy-related molecules may increase the chemosensitivity of cancer cells … hifi资源哪里找WebFeb 28, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers. hifi资源网站WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using CRISPR gene scissors, they identified the NAE1 gene as its driver. Inhibiting this resistance mediator by adding the NAE1 inhibitor MLN4924 not only restores the effect of cisplatin, … how far is blairs va from lynchburg vaWebOct 23, 2003 · The mechanisms responsible for cisplatin resistance are several, and contribute to the multifactorial nature of the problem. Resistance mechanisms that limit the extent of DNA damage... hifi 和 hiresWebThe majority of cisplatin DNA lesions are repaired by the nucleotide excision repair (NER) system [ 79, 80]. One proposed mechanism for cisplatin resistance involves high expression of the high-mobility group box protein 1 (HMGB1) in TGCT cells [ 81]. hif jobs